When there is no complexation between these species a and b, the value of property is additive. Use of charge transfer complexation reactions for the spectrophotometric determination of sumatriptan in pharmaceuticals. The essence of pharmaceutics, as many of the chapters in the two volumes of this book. Complexation, a term with a broad definition, is used in the context of this chapter to characterize the covalent or noncovalent interactions between two or more compounds that are capable of independent existence. Complexation and protein binding complexes or coordination compounds, according to the classic definition, result from a donoracceptor mechanism or lewis acidbase reaction between two or more different chemical constituents. Any modern text on the design and evaluation merge pdf files mac free download of therapeutic products must place michel serres parasite pdf. Complexation is the association between two or more molecules to form a non bonded entity with a welldefined stoichiometry. The difference between a donoracceptor and a charge transfercomplex is that in the latter type, resonance makes the main contribution to complexation, whereas in the former, london dispersion forces and dipoledipole interactions contribute more to the stability of the complex. In case of complexation, these properties change, i. International journal of pharmaceutics vol 491, issues 1. Pdf cyclodextrins are oligosaccharides, specifically cyclic alpha1,4dglucose oligomers, that possess a conelike shape resulting in a hydrophobic. Drug molecules can form complexes with other small molecules or with macromolecules such as proteins.
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